Biological and molecular profile of fracture non-union tissue: current insights
Panteli, M, Pountos, I, Jones, E et al. (1 more author)
(2015)
Biological and molecular profile of fracture non-union tissue: current insights.
Journal of Cellular and Molecular Medicine, 19 (4).
pp. 685-713.
ISSN 1582-1838
Abstract
Delayed bone healing and non-union occur in approximately 10% of long bone fractures. Despite intense investigations and progress in understanding the processes governing bone healing, the specific pathophysiological characteristics of the local microenvironment leading to non-union remain obscure. The clinical findings and radiographic features remain the two important landmarks of diagnosing non-unions and even when the diagnosis is established there is debate on the ideal timing and mode of intervention. In an attempt to understand better the pathophysiological processes involved in the development of fracture non-union, a number of studies have endeavoured to investigate the biological profile of tissue obtained from the non-union site and analyse any differences or similarities of tissue obtained from different types of non-unions. In the herein study, we present the existing evidence of the biological and molecular profile of fracture non-union tissue.
Metadata
Authors/Creators:
Panteli, M
Pountos, I
Jones, E
Giannoudis, PV
Copyright, Publisher and Additional Information:
(c) 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords:
non-union(s); human tissue; bone morphogenic protein(s); mesenchymal stem cell(s)
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)