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The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis

Furley, A. (2001) The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis. Genome Biology, 2 (9). reviews1026.1 - reviews1026.5. ISSN 1465-6906

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Abstract

A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.

Item Type: Article
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield) > Centre for Developmental Genetics (Sheffield)
The University of Sheffield > University of Sheffield Research Centres and Institutes > Centre for Developmental Genetics (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 02 Oct 2009 10:40
Last Modified: 08 Oct 2009 15:09
Published Version: http://genomebiology.com/2001/2/9/reviews/1026
Status: Published
Publisher: Biomed Central
Identification Number: 10.1186/gb-2001-2-9-reviews1026
URI: http://eprints.whiterose.ac.uk/id/eprint/9652

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