Furley, A. (2001) The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis. Genome Biology, 2 (9). reviews1026.1 - reviews1026.5. ISSN 1465-6906
A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield) > Centre for Developmental Genetics (Sheffield)
The University of Sheffield > University of Sheffield Research Centres and Institutes > Centre for Developmental Genetics (Sheffield)
|Depositing User:||Sheffield Import|
|Date Deposited:||02 Oct 2009 10:40|
|Last Modified:||08 Oct 2009 15:09|