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Tissue factor, angiogenesis and tumour progression

Bluff, J., Brown, N., Reed, M. and Staton, C. (2008) Tissue factor, angiogenesis and tumour progression. Breast Cancer Research, 10 (2). p. 204. ISSN 1465-5411

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Tissue factor, the primary initiator of the coagulation cascade, maintains vascular integrity in response to injury. It is now recognised that, in addition to the role as a procoagulant activator, tissue factor participates in many tumour-related processes that contribute to malignant disease progression. The present review details the recent evidence supporting a role for tissue factor in tumour haemostasis, angiogenesis, metastasis and malignant cell survival. Furthermore, future research directions are discussed that may enhance our understanding of the role and regulation of this protein, which could ultimately lead to the innovative design and development of new anticancer therapies.

Item Type: Article
Copyright, Publisher and Additional Information: © 2008 BioMed Central Ltd
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 02 Oct 2009 14:17
Last Modified: 08 Oct 2009 09:25
Published Version: http://breast-cancer-research.com/content/10/2/204
Status: Published
Publisher: Biomed Central
Identification Number: 10.1186/bcr1871
URI: http://eprints.whiterose.ac.uk/id/eprint/9610

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