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Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review

Balasubramanian, S.P., Azmy, I.A.F., Higham, S.E., Wilson, A.G., Cross, S.S., Cox, A., Brown, N.J. and Reed, M.W. (2006) Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review. BMC Cancer, 6 (1). p. 188. ISSN 1471-2407

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Interleukins and cytokines play an important role in the pathogenesis of many solid cancers. Several single nucleotide polymorphisms (SNPs) identified in cytokine genes are thought to influence the expression or function of these proteins and many have been evaluated for their role in inflammatory disease and cancer predisposition. The aim of this study was to evaluate any role of specific SNPs in the interleukin genes IL1A, IL1B, IL1RN, IL4R, IL6 and IL10 in predisposition to breast cancer susceptibility and severity.


Candidate single nucleotide polymorphisms (SNPs) in key cytokine genes were genotyped in breast cancer patients and in appropriate healthy volunteers who were similar in age, race and sex. Genotyping was performed using a high throughput allelic discrimination method. Data on clinico-pathological details and survival were collected. A systematic review of Medline English literature was done to retrieve previous studies of these polymorphisms in breast cancer.


None of the polymorphisms studied showed any overall predisposition to breast cancer susceptibility, severity or to time to death or occurrence of distant metastases. The results of the systematic review are summarised.


Polymorphisms within key interleukin genes (IL1A, IL1B, IL1RN, IL4R, IL6 and IL10 do not appear to play a significant overall role in breast cancer susceptibility or severity.

Item Type: Article
Copyright, Publisher and Additional Information: © 2006 Balasubramanian et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 08 Oct 2009 10:33
Last Modified: 08 Oct 2009 11:56
Published Version: http://www.biomedcentral.com/1471-2407/6/188
Status: Published
Publisher: BioMed central
Identification Number: 10.1186/1471-2407-6-188
URI: http://eprints.whiterose.ac.uk/id/eprint/9603

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