Huf, G., Coutinho, E.S.F., Adams, C.E., Borges, R.V.S., Ferreira, M.A.V., Silva, F.J.F., Pereira, A.J.C.R., Abreu, A.M., Lugao, S.M., Santos, M.P.C.P., Gewandsznajder, M., Mercadante, V.R.P., Lange, W. and Dias, C.L. (2003) Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. BMJ, 327 (7417). pp. 708-711. ISSN 0959-8138Full text available as:
Available under licence : See the attached licence file.
OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness.
DESIGN: Pragmatic, randomised clinical trial.
SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil.
SUBJECTS: 301 aggressive or agitated people.
INTERVENTIONS: Open treatment with intramuscular midazolam or intramuscular haloperidol plus promethazine.
MAIN OUTCOME MEASURES: Patients tranquil or sedated at 20 minutes. Secondary outcomes: patients tranquil or asleep by 40, 60, and 120 minutes; restrained or given extra drugs within 2 hours; severe adverse events; another episode of agitation or aggression; needing extra visits from doctor during first 24 hours; overall antipsychotic load in first 24 hours; and not discharged by two weeks.
|Copyright, Publisher and Additional Information:||© 2003 BMJ Publishing Group Ltd.|
|Institution:||The University of Leeds|
|Academic Units:||The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds)|
|Depositing User:||Sherpa Assistant|
|Date Deposited:||13 Mar 2006|
|Last Modified:||17 Jun 2014 06:15|