A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

Simpson, J.E., Ince, P.G., Matthews, F.E. et al. (7 more authors) (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41 (4). pp. 483-496. ISSN 0305-1846

Abstract

Metadata

Authors/Creators:
  • Simpson, J.E.
  • Ince, P.G.
  • Matthews, F.E.
  • Shaw, P.J.
  • Heath, P.R.
  • Brayne, C.
  • Garwood, C.
  • Higginbottom, A.
  • Wharton, S.B.
  • Ageing, M.R.C.C.F.
Copyright, Publisher and Additional Information: © 2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: cognitive impairment; DNA damage response; DNA-PKcs; neurone; H2AX
Dates:
  • Published: June 2015
  • Accepted: 27 November 2014
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Depositing User: Symplectic Sheffield
Date Deposited: 21 Jan 2016 09:41
Last Modified: 21 Jan 2016 09:41
Published Version: http://dx.doi.org/10.1111/nan.12202
Status: Published
Publisher: Wiley
Refereed: Yes
Identification Number: https://doi.org/10.1111/nan.12202
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