Susceptibility of Clostridium difficile isolates of varying antimicrobial resistance phenotypes to SMT19969 and 11 comparators.

Abstract

We determined the in vitro activity of SMT19969 and 11 comparators, including metronidazole, vancomycin and fidaxomicin, against 107 C. difficile isolates of different antimicrobial resistance phenotypes. Fidaxomicin and SMT19969 were most active. Geometric mean fidaxomicin and SMT19969 MICs were highest in ribotypes known to show multiple resistance. Co-resistance to linezolid and moxifloxacin was evident in ribotypes 001, 017, 027 and 356. High-level ceftriaxone resistance in ribotypes 356 and 018 was location-linked.

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Authors/Creators:	Freeman, J Vernon, J Vickers, R Wilcox, MH
Copyright, Publisher and Additional Information:	© 2015 Freeman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Dates:	Accepted: 4 November 2015 Published: January 2016
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	09 Dec 2015 14:52
Last Modified:	13 May 2018 01:22
Published Version:	http://dx.doi.org/10.1128/AAC.02000-15
Status:	Published
Publisher:	American Society for Microbiology
Identification Number:	https://doi.org/10.1128/AAC.02000-15
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Susceptibility of Clostridium difficile isolates of varying antimicrobial resistance phenotypes to SMT19969 and 11 comparators.

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