The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

Fluteau, A., Ince, P.G., Minett, T. et al. (10 more authors) (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609. pp. 11-17. ISSN 0304-3940

Abstract

Metadata

Authors/Creators:
  • Fluteau, A.
  • Ince, P.G.
  • Minett, T.
  • Matthews, F.E.
  • Brayne, C.
  • Garwood, C.J.
  • Ratcliffe, L.E.
  • Morgan, S.
  • Heath, P.R.
  • Shaw, P.J.
  • Wharton, S.B.
  • Simpson, J.E.
  • MRC Cognitive Function Ageing Neuropathology Study Group,
Copyright, Publisher and Additional Information: © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Keywords: Ageing brain; Alzheimer’s; Astrocyte; DNA damage response; FOXO3a; Glutamine synthetase; Pathology; neurone
Dates:
  • Published: 16 November 2015
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
ALZHEIMERS RESEARCH UKART-PG2010-5
MEDICAL RESEARCH COUNCILMR/J004308/1
Depositing User: Symplectic Sheffield
Date Deposited: 18 Jan 2016 16:31
Last Modified: 18 Jan 2016 16:31
Published Version: http://dx.doi.org/10.1016/j.neulet.2015.10.001
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: https://doi.org/10.1016/j.neulet.2015.10.001
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