Missing steps in a staircase: A qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials

Dimairo, M., Boote, J., Julious, S.A. et al. (2 more authors) (2015) Missing steps in a staircase: A qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16. 430. ISSN 1745-6215

Abstract

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Authors/Creators:
  • Dimairo, M.
  • Boote, J.
  • Julious, S.A.
  • Nicholl, J.P.
  • Todd, S.
Copyright, Publisher and Additional Information: © 2015 Dimairo et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Adaptive designs; Flexible designs; Qualitative interviews; Confirmatory trials; Phase 3; Clinical trials; Publicly funded trials; Early stopping; Interim analyses
Dates:
  • Published: 28 September 2015
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 07 Oct 2015 13:56
Last Modified: 07 Oct 2015 13:56
Published Version: http://dx.doi.org/10.1186/s13063-015-0958-9
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/s13063-015-0958-9

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