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Change in background context disrupts performance on visual paired comparison following hippocampal damage

Pascalis, O., Hunkin, N.M., Bachevalier, J. and Mayes, A.R. (2009) Change in background context disrupts performance on visual paired comparison following hippocampal damage. Neuropsychologia, 47 (10). pp. 2107-2113. ISSN 0028-3932


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The medial temporal lobe plays a critical role in recognition memory but, within the medial temporal lobe, the precise neural structures underlying recognition memory remain equivocal. in this study, visual paired comparison (VPC) was used to investigate recognition memory in a human patient (YR), who had a discrete lesion of the hippocampus, and a group of monkeys with neonatal hippocampal lesions, which included the dentate gyrus, and a portion of parahippocampal region. Participants were required to view a picture of an object on a coloured background. Immediately afterwards, this familiar object was shown again, this time paired with a novel object. All participants displayed a novelty preference, provided the background on which the objects were shown was the same as the one used during the learning phase. When the background of the familiar object was changed between initial familiarization and test, only the control subjects showed a novelty preference; the hippocampal-lesioned monkeys and patient YR showed null preference. The results are interpreted within Eichenbaum and Bunsey's [Eichenbaum, H., & Bunsey, M. (1995). On the binding of associations in memory: Clues from studies on the role of the hippocampal region in paired-associate learning. Current Directions in Psychological Science, 4, 19-23] proposal that the hippocampus facilitates the formation of a flexible representation of the elements that make up a stimulus whereas the parahippocampal region is involved in the formation of a fused representation. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Copyright, Publisher and Additional Information: © 2009 Elsevier. This is an author produced version of a paper subsequently published in Neuropsychologia. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Visual recognition; Memory; Amnesic patient; Hippocampal
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 17 Jul 2009 10:34
Last Modified: 08 Feb 2013 16:58
Published Version: http://dx.doi.org/10.1016/j.neuropsychologia.2009....
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: 10.1016/j.neuropsychologia.2009.04.001
URI: http://eprints.whiterose.ac.uk/id/eprint/9010

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