Clayton, R.H and Holden, A.V (2004) Filament behavior in a computational model of ventricular fibrillation in the canine heart. IEEE Transactions on Biomedical Engineering Bme, 51 (1). pp. 28-34. ISSN 0018-9294
Abstract
The aim of this paper was to quantify the behavior of filaments in a computational model of re-entrant ventricular fibrillation. We simulated cardiac activation in an anisotropic monodomain with excitation described by the Fenton-Karma model with Beeler-Reuter restitution, and geometry by the Auckland canine ventricle. We initiated re-entry in the left and right ventricular free walls, as well as the septum. The number of filaments increased during the first 1.5 s before reaching a plateau with a mean value of about 36 in each simulation. Most re-entrant filaments were between 10 and 20 mm long. The proportion of filaments touching the epicardial surface was 65%, but most of these were visible for much less than one period of re-entry. This paper shows that useful information about filament dynamics can be gleaned from models of fibrillation in complex geometries, and suggests that the interplay of filament creation and destruction may offer a target for antifibrillatory therapy
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Copyright 2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
Depositing User: | Miss Anthea Tucker |
Date Deposited: | 10 Jul 2009 11:59 |
Last Modified: | 07 Jun 2014 02:52 |
Published Version: | http://dx.doi.org/10.1109/TBME.2003.820356 |
Status: | Published |
Publisher: | Institute of Electrical and Electronics Engineers |
Refereed: | Yes |
Identification Number: | 10.1109/TBME.2003.820356 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:8741 |