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Influence of cardiac tissue anisotropy on re-entrant activation in computational models of ventricular fibrillation

Clayton, R.H. (2009) Influence of cardiac tissue anisotropy on re-entrant activation in computational models of ventricular fibrillation. Physica D-Nonlinear Phenomena, 238 (11-12). pp. 951-961. ISSN 0167-2789


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The aim of this study was to establish the role played by anisotropic diffusion in (i) the number of filaments and epicardial phase singularities that sustain ventricular fibrillation in the heart, (ii) the lifetimes of filaments and phase singularities, and (iii) the creation and annihilation dynamics of filaments and phase singularities. A simplified monodomain model of cardiac tissue was used, with membrane excitation described by a simplified 3-variable model. The model was configured so that a single re-entrant wave was unstable, and fragmented into multiple re-entrant waves. Re-entry was then initiated in tissue slabs with varying anisotropy ratio. The main findings of this computational study are: (i) anisotropy ratio influenced the number of filaments Sustaining simulated ventricular fibrillation, with more filaments present in simulations with smaller values of transverse diffusion coefficient, (ii) each re-entrant filament was associated with around 0.9 phase singularities on the surface of the slab geometry, (iii) phase singularities were longer lived than filaments, and (iv) the creation and annihilation of filaments and phase singularities were linear functions of the number of filaments and phase singularities, and these relationships were independent of the anisotropy ratio. This study underscores the important role played by tissue anisotropy in cardiac ventricular fibrillation.

Item Type: Article
Copyright, Publisher and Additional Information: © 2009 Elsevier. This is an author produced version of a paper subsequently published in Physica D-Nonlinear Phenomena. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Cardiac arrhythmia; Re-entry; Ventricular fibrillation; Excitable medium; Spatiotemporal complexity
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 23 Jul 2009 09:06
Last Modified: 15 Sep 2014 01:36
Published Version: http://dx.doi.org/10.1016/j.physd.2008.06.008
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: 10.1016/j.physd.2008.06.008
URI: http://eprints.whiterose.ac.uk/id/eprint/8738

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