Common variants in FOXP1 are associated with generalized vitiligo

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).

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Authors/Creators:	Jin, Y. Birlea, S.A. Fain, P.R. Mailloux, C.M. Riccardi, S.L. Gowan, K. Holland, P.J. Bennett, D.C. Wallace, M.R. McCormack, W.T. Kemp, E.H. Gawkrodger, D.J. Weetman, A.P. Picardo, M. Leone, G. Taïeb, A. Jouary, T. Ezzedine, K. van Geel, N. Lambert, J. Overbeck, A. Spritz, R.A.
Copyright, Publisher and Additional Information:	Copyright © 2010, Rights Managed by Nature Publishing Group. This is an author produced version of a paper subsequently published in Nature Genetics. Uploaded in accordance with the publisher's self-archiving policy.
Keywords:	Genome-wide association; Essential transcriptional regulator; T-Cells; Susceptibility loci; Autoimmunity; Genetics; Diseases; IDDM8
Dates:	Published: 6 June 2010
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	07 Oct 2015 13:34
Last Modified:	23 Nov 2016 22:59
Published Version:	https://doi.org/10.1038/ng.602
Status:	Published
Publisher:	Nature Publishing Group
Refereed:	Yes
Identification Number:	https://doi.org/10.1038/ng.602

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Common variants in FOXP1 are associated with generalized vitiligo

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