Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

Lolicato, M, Bucchi, A, Arrigoni, C et al. (13 more authors) (2014) Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nature Chemical Biology, 10 (6). 457 - 462. ISSN 1552-4469



  • Lolicato, M
  • Bucchi, A
  • Arrigoni, C
  • Zucca, S
  • Nardini, M
  • Schroeder, I
  • Simmons, K
  • Aquila, M
  • DiFrancesco, D
  • Bolognesi, M
  • Schwede, F
  • Kashin, D
  • Fishwick, CW
  • Johnson, AP
  • Thiel, G
  • Moroni, A
Copyright, Publisher and Additional Information: (c) 2014, Nature Publishing Group. This is an author produced version of a paper published in Nature Chemical Biology. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Animals; binding sites; blotting, western; crystallography, x-ray; cyclic AMP; cyclic GMP; dinucleoside phosphates; HEK293 Cells; high-throughput screening assays; humans; hyperpolarization-activated cyclic nucleotide-gated channels; ion channel gating; inbred mice C57BL; ligands; mice; molecular docking simulation; molecular structure; muscle proteins; myocytes, cardiac; patch-clamp techniques; potassium channels; sinoatrial node; small molecule libraries; transfection
  • Published: June 2014
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Chemistry (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 26 Mar 2015 10:39
Last Modified: 18 Jan 2018 21:59
Published Version:
Status: Published
Publisher: Nature Publishing Group
Identification Number:

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