Khuphe, M, Kazlauciunas, A, Huscroft, M et al. (1 more author) (2015) The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery. Chemical Communications, 51 (8). 1520 - 1523. ISSN 1359-7345
Abstract
The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.
Metadata
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| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 09 Feb 2015 14:15 |
| Last Modified: | 30 Jun 2020 14:49 |
| Published Version: | http://dx.doi.org/10.1039/c4cc08387c |
| Status: | Published |
| Publisher: | Royal Society of Chemistry |
| Identification Number: | https://doi.org/10.1039/c4cc08387c |
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