Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors.
Sedgwick, B, Riches, K, Bageghni, SA et al. (3 more authors)
(2014)
Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors.
Cardiovascular Pathology, 23 (4).
204 - 210.
ISSN 1054-8807
Abstract
Type 2 diabetes mellitus (T2DM) promotes adverse myocardial remodeling and increased risk of heart failure; effects that can occur independently of hypertension or coronary artery disease. As cardiac fibroblasts (CFs) are key effectors of myocardial remodeling, we investigated whether inherent phenotypic differences exist in CF derived from T2DM donors compared with cells from nondiabetic (ND) donors.
Metadata
Authors/Creators:
Sedgwick, B
Riches, K
Bageghni, SA
O'Regan, DJ
Porter, KE
Turner, NA
Copyright, Publisher and Additional Information:
(c) 2014 Elsevier Inc. Uploaded in accordance with the publisher's self-archiving policy. NOTICE: this is the author’s version of a work that was accepted for publication in Cardiovascular Physiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cardiovascular Physiology, 23, 4, (2014) DOI 10.1016/j.carpath.2014.03.004
Keywords:
Cardiac fibroblasts; Type I collagen; Human; Heart; Type 2 diabetes
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)