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Long term behavior of lithographically prepared in vitro neuronal networks

Segev, R., Benveniste, M., Hulata, E., Cohen, N., Palevski, A., Kapon, E., Shapira, Y. and Ben-Jacob, E. (2002) Long term behavior of lithographically prepared in vitro neuronal networks. Physical Review Letters, 88 (11). Art. No. 118102. ISSN 1079-7114


We measured the long term spontaneous electrical activity of neuronal networks with different sizes, grown on lithographically prepared substrates and recorded with multi-electrode-array technology. The time sequences of synchronized bursting events were used to characterize network dynamics. All networks exhibit scale-invariant Lévy distributions and long-range correlations. These observations suggest that different-size networks self-organize to adjust their activities over many time scales. As predictions of current models differ from our observations, this calls for revised models.

Item Type: Article
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Engineering (Leeds) > School of Computing (Leeds)
Depositing User: Miss Jamie Grant
Date Deposited: 12 Mar 2009 18:44
Last Modified: 15 Sep 2014 01:38
Published Version: http://dx.doi.org/10.1103/PhysRevLett.88.118102
Status: Published
Publisher: American Physical Society
Identification Number: 10.1103/PhysRevLett.88.118102
URI: http://eprints.whiterose.ac.uk/id/eprint/7964

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