Almogy, G., Cohen, N., Stöcker, S. and Stone, L. (2002) Immune response and virus population composition: HIV as a case study. Proceedings of the Royal Society B: Biological Sciences, 269 (1493). pp. 809-815. ISSN 1471-2954Full text available as:
Based on the current understanding of the immune response, we present what we believe to be a new model of intrahost virus dynamics. The model takes into account the relationship between virus replication rate and the level of antigen displayed by infected cells, and shows how the cell-directed immune response controls both virus load and virus replication rate. In contrast to conventional wisdom, it shows that the predominant virus variant does not necessarily have the highest replication rate. A strong immune response produces a selective advantage for latent viruses, whereas a deteriorating immune response invites in viruses of higher replication rates. The model is analysed in light of the well-studied HIV/AIDS disease progression, and shows how a wide range of major, seemingly unrelated issues in the study of HIV may be accounted for in a simple and uni® ed manner.
|Keywords:||HIV; AIDS; evolution of virulence; immune response; model; virus dynamics|
|Institution:||The University of Leeds|
|Academic Units:||The University of Leeds > Faculty of Engineering (Leeds) > School of Computing (Leeds)|
|Depositing User:||Miss Jamie Grant|
|Date Deposited:||12 Mar 2009 18:35|
|Last Modified:||09 Jun 2014 16:19|