Gillet, V.J. (2008) New directions in library design and analysis. Current Opinion in Chemical Biology, 12 (3). 372 - 378.
Abstract
The high costs associated with high-throughput screening (HTS) coupled with the limited coverage and bias of current screening collections is such that diversity analysis continues to be an important criterion in lead generation. Whereas early approaches to diversity analysis were based on traditional descriptors such as two-dimensional fingerprints a recent emphasis has been on assessing scaffold coverage to ensure that a variety of different chemotypes are represented. Moreover, whether designing diverse or focused libraries, it is widely recognised that designs should aim to achieve a balance in a number of different properties and multiobjective optimisation provides an effective way of achieving such designs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2008 Elsevier. This is an author produced version of a paper subsequently published in Current Opinion in Chemical Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Multiobjective genetic algorithm; Combinatorial libraries; Biological-activity; Structural diversity; Molecular diversity; Screening libraries; Chemical libraries; Focused libraries; Natural-products; Lead generation. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Social Sciences (Sheffield) > Information School (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Apr 2014 15:04 |
Last Modified: | 23 Apr 2014 08:03 |
Published Version: | http://dx.doi.org/10.1016/j.cbpa.2008.02.015 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.cbpa.2008.02.015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:78610 |