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Firdaus-Raih, M., Harrison, A.M., Willett, P. et al. (1 more author) (2011) Novel base triples in RNA structures revealed by graph theoretical searching methods. BMC Bioinformatics, 12. pp. 1-13.
Abstract
Background - Highly hydrogen bonded base interactions play a major part in stabilizing the tertiary structures of complex RNA molecules, such as transfer-RNAs, ribozymes and ribosomal RNAs.
Results - We describe the graph theoretical identification and searching of highly hydrogen bonded base triples, where each base is involved in at least two hydrogen bonds with the other bases. Our approach correlates theoretically predicted base triples with literature-based compilations and other actual occurrences in crystal structures. The use of ‘fuzzy’ search tolerances has enabled us to discover a number of triple interaction types that have not been previously recorded nor predicted theoretically.
Conclusions - Comparative analyses of different ribosomal RNA structures reveal several conserved base triple motifs in 50S rRNA structures, indicating an important role in structural stabilization and ultimately RNA function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2011 Firdaus-Raih et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Peptide-Bond Formation; Large Ribosomal-Subunit; Phenylalanine Transfer-RNA; Delta Virus Ribozyme; Angstrom Resolution; Crystal-Structure; 3-Dimensional Structure; Hammerhead Ribozyme; Binding-Sites; Catalysis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Social Sciences (Sheffield) > Information School (Sheffield) |
Depositing User: | Miss Anthea Tucker |
Date Deposited: | 04 Mar 2014 13:47 |
Last Modified: | 12 Jun 2014 11:25 |
Published Version: | http://dx.doi.org/10.1186/1471-2105-12-S13-S2 |
Status: | Published |
Publisher: | BioMed Central |
Refereed: | Yes |
Identification Number: | 10.1186/1471-2105-12-S13-S2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77367 |
Available Versions of this Item
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Novel base triples in RNA structures revealed by graph theoretical searching methods. (deposited 09 Jan 2013 16:16)
- Novel base triples in RNA structures revealed by graph theoretical searching methods. (deposited 04 Mar 2014 13:47) [Currently Displayed]