Kinnell, A, Harman, T, Bingham, M et al. (2 more authors) (2012) Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction. Tetrahedron, 68 (37). 7719 - 7722. ISSN 0040-4020
Abstract
A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon-carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in which both the organo- and enzyme-catalysed reactions could be performed in the same aqueous buffer system. The reaction described is the first example of a one-pot, three-component reaction in which the two carbon-carbon bond-forming processes are catalysed using the combination of an organocatalyst and an enzyme.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012, Elsevier. This is an author produced version of a paper published in Tetrahedron. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Dec 2013 10:58 |
Last Modified: | 10 Dec 2013 13:14 |
Published Version: | http://dx.doi.org/10.1016/j.tet.2012.02.010 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tet.2012.02.010 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77266 |