MacLellan, P and Nelson, A (2013) A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds. Chemical Communications, 49 (24). 2383 - 2393. ISSN 1359-7345
Abstract
Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic. This feature article outlines a comprehensive conceptual framework that may be used to capture, analyse and plan synthetic approaches that may address this historically uneven exploration. Illustrative examples of synthetic approaches that target, or have potential to target, broad tracts of lead-like chemical space are presented within the context of this conceptual framework. Particular emphasis is placed on synthetic approaches that enable the combinatorial variation of molecular scaffold, particularly within the boundaries of lead-like chemical space.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013, Royal Society of Chemistry. This is an author produced version of a paper published in Chemical Communications. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Amination; Bicyclo Compounds; Catalysis; Cyclization; Cycloaddition Reaction; Heterocyclic Compounds; Metals; Models, Chemical; Pyrrolidinones |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Dec 2013 11:36 |
Last Modified: | 01 Feb 2014 01:38 |
Published Version: | http://dx.doi.org/10.1039/c2cc38184b |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Refereed: | Yes |
Identification Number: | 10.1039/c2cc38184b |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77265 |