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Materials for phantoms for terahertz pulsed imaging

Walker, G.C., Berry, E., Smye, S.E. and Brettle, D.S. (2004) Materials for phantoms for terahertz pulsed imaging. Physics in Medicine and Biology, 49. N363-N369. ISSN 0031-9155

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Phantoms are commonly used in medical imaging for quality assurance, calibration, research and teaching. They may include test patterns or simulations of organs, but in either case a tissue substitute medium is an important component of the phantom. The aim of this work was to identify materials suitable for use as tissue substitutes for the relatively new medical imaging modality terahertz pulsed imaging. Samples of different concentrations of the candidate materials TX151 and napthol green dye were prepared, and measurements made of the frequency-dependent absorption coefficient (0.5 to 1.5 THz) and refractive index (0.5 to 1.0 THz). These results were compared qualitatively with measurements made in a similar way on samples of excised human tissue (skin, adipose tissue and striated muscle). Both materials would be suitable for phantoms where the dominant mechanism to be simulated is absorption (similar to ∼100 cm(-1) at 1 THz) and where simulation of the strength of reflections from boundaries is not important; for example, test patterns for spatial resolution measurements. Only TX151 had a frequency-dependent refractive index close to that of tissue, and could therefore be used to simulate the layered structure of skin, the complexity of microvasculature or to investigate frequency-dependent interference effects that have been noted in terahertz images.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2004 IOP Publishing Ltd. This is an author produced version of a paper published in Physics in Medicine and Biology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds)
Depositing User: Elizabeth Berry
Date Deposited: 13 Mar 2006
Last Modified: 10 Jun 2014 08:30
Published Version: http://stacks.iop.org/0031-9155/49/N363
Status: Published
Refereed: Yes
Identification Number: 10.1088/0031-9155/49/21/N01
URI: http://eprints.whiterose.ac.uk/id/eprint/762

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