Firth, A.G., Fairlamb, I.J.S., Darley, K. and Baumann, C.G. (2006) Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: Fluorescence properties of compact conjugated acetylenes containing a purine ring. Tetrahedron Letters, 47 (21). pp. 3529-3533. ISSN 0040-4039Full text not available from this repository.
A practical Sonogashira alkynylation protocol for the preparation of 8-alkynylated adenosines and guanosines has been developed. Protection of the sugar hydroxyl substituents is not required; protection hinders the purification of these products. A preliminary fluorescent study is reported, which shows that the presence of a substituent on the phenylene ring influences the fluorescent properties considerably, an outcome that could be utilized in biological applications.
|Institution:||The University of York|
|Academic Units:||The University of York > Chemistry (York)
The University of York > Biology (York)
|Depositing User:||York RAE Import|
|Date Deposited:||11 Feb 2009 12:30|
|Last Modified:||11 Feb 2009 12:30|
|Publisher:||Elsevier Science B.V., Amsterdam.|