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Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: Fluorescence properties of compact conjugated acetylenes containing a purine ring

Firth, A.G., Fairlamb, I.J.S., Darley, K. and Baumann, C.G. (2006) Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: Fluorescence properties of compact conjugated acetylenes containing a purine ring. Tetrahedron Letters, 47 (21). pp. 3529-3533. ISSN 0040-4039

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Abstract

A practical Sonogashira alkynylation protocol for the preparation of 8-alkynylated adenosines and guanosines has been developed. Protection of the sugar hydroxyl substituents is not required; protection hinders the purification of these products. A preliminary fluorescent study is reported, which shows that the presence of a substituent on the phenylene ring influences the fluorescent properties considerably, an outcome that could be utilized in biological applications.

Item Type: Article
Academic Units: The University of York > Chemistry (York)
The University of York > Biology (York)
Depositing User: York RAE Import
Date Deposited: 11 Feb 2009 12:30
Last Modified: 11 Feb 2009 12:30
Published Version: http://dx.doi.org/10.1016/j.tetlet.2006.03.100
Status: Published
Publisher: Elsevier Science B.V., Amsterdam.
Identification Number: 10.1016/j.tetlet.2006.03.100
URI: http://eprints.whiterose.ac.uk/id/eprint/7565

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