Rrp47 and the function of the Sas10/C1D domain

The Sas10/C1D domain is found in a small group of eukaryotic proteins that have functions in RNA processing events, translational control and DNA repair mechanisms. The domain is predicted to be helical in nature and comprises approximately 80 amino acid residues. While the Sas10/C1D domain has yet to be functionally characterised, available data suggest that this domain forms a binding surface for specific interactions with other proteins and can concomitantly interact with RNA or DNA. This property of the Sas10/C1D domain may facilitate this family of proteins to dock other proteins onto nucleic acid substrates.