Cook, J.R., Drummond, M., Glick, H. and Heyse, J.F. (2003) Assessing the appropriateness of combining economic data from multinational clinical trials. Statistics in Medicine, 22 (12). pp. 1955-1976. ISSN 0277-6715
Because of the potential for large variability among countries in the utilization and cost of health care resources, it is important to assess the appropriateness of combining economic data across the countries in a multinational clinical economic trial. We show how available tests for interaction can be applied to economic endpoints, including cost-effectiveness ratios and net health benefits. This analysis includes a characterization of possible interactions being quantitative or qualitative in nature. In the absence of interaction, a pooled estimate of the economic endpoint should be representative of the participating countries. We explore the analytic issues by further analysing data from the Scandinavian Simvastatin Survival Study (4S).
|Institution:||The University of York|
|Academic Units:||The University of York > Centre for Health Economics (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||12 Feb 2009 11:34|
|Last Modified:||12 Feb 2009 11:34|
|Publisher:||John Wiley & Sons|