White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

Assessing the appropriateness of combining economic data from multinational clinical trials

Cook, J.R., Drummond, M., Glick, H. and Heyse, J.F. (2003) Assessing the appropriateness of combining economic data from multinational clinical trials. Statistics in Medicine, 22 (12). pp. 1955-1976. ISSN 0277-6715

Full text not available from this repository.

Abstract

Because of the potential for large variability among countries in the utilization and cost of health care resources, it is important to assess the appropriateness of combining economic data across the countries in a multinational clinical economic trial. We show how available tests for interaction can be applied to economic endpoints, including cost-effectiveness ratios and net health benefits. This analysis includes a characterization of possible interactions being quantitative or qualitative in nature. In the absence of interaction, a pooled estimate of the economic endpoint should be representative of the participating countries. We explore the analytic issues by further analysing data from the Scandinavian Simvastatin Survival Study (4S).

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Centre for Health Economics (York)
Depositing User: York RAE Import
Date Deposited: 12 Feb 2009 11:34
Last Modified: 12 Feb 2009 11:34
Published Version: http://dx.doi.org/10.1002/sim.1389
Status: Published
Publisher: John Wiley & Sons
Identification Number: 10.1002/sim.1389
URI: http://eprints.whiterose.ac.uk/id/eprint/7504

Actions (repository staff only: login required)