Coles, M.C., Veiga-Fernandes, H., Foster, K.E., Norton, T., Pagakis, S.N., Seddon, B. and Kioussis, D. (2006) Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proceedings of the National Academy of Sciences of the United States of America, 103 (36). pp. 13457-13462. ISSN 0027-8424
Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rγ−/− Rag2 −/−). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rγ−/− Rag2 −/− LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r+ TCR+ T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.
|Institution:||The University of York|
|Academic Units:||The University of York > Biology (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||18 Feb 2009 10:30|
|Last Modified:||18 Feb 2009 10:30|
|Publisher:||National Academy of Sciences; 1999|