Healy, M.P., Parsons, A.F. and Rawlinson, J.G.T. (2005) Consecutive approach to alkenes that combines radical addition of phosphorus hydrides with Horner-Wadsworth-Emmons-type reactions. Organic Letters, 7 (8). pp. 1597-1600. ISSN 1523-7060
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Published Version: http://dx.doi.org/10.1021/ol050292e
Abstract
Addition of diethyl thiophosphite to terminal alkenes, in the presence of a radical initiator, followed by deprotonation of the phosphonothioate and reaction with a ketone, offers a concise one-pot approach to substituted alkenes. This novel method, which can incorporate alkylation or acylation steps, can be applied to the stereoselective formation of sterically hindered tri- and tetrasubstituted alkenes.
| Item Type: | Article |
|---|---|
| Academic Units: | The University of York > Chemistry (York) |
| Depositing User: | York RAE Import |
| Date Deposited: | 12 Mar 2009 12:26 |
| Last Modified: | 12 Mar 2009 12:26 |
| Published Version: | http://dx.doi.org/10.1021/ol050292e |
| Status: | Published |
| Publisher: | The American Chemical Society |
| Identification Number: | 10.1021/ol050292e |
| URI: | http://eprints.whiterose.ac.uk/id/eprint/7126 |
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