Healy, M.P., Parsons, A.F. and Rawlinson, J.G.T. (2005) Consecutive approach to alkenes that combines radical addition of phosphorus hydrides with Horner-Wadsworth-Emmons-type reactions. Organic Letters, 7 (8). pp. 1597-1600. ISSN 1523-7060
Addition of diethyl thiophosphite to terminal alkenes, in the presence of a radical initiator, followed by deprotonation of the phosphonothioate and reaction with a ketone, offers a concise one-pot approach to substituted alkenes. This novel method, which can incorporate alkylation or acylation steps, can be applied to the stereoselective formation of sterically hindered tri- and tetrasubstituted alkenes.
|Institution:||The University of York|
|Academic Units:||The University of York > Chemistry (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||12 Mar 2009 12:26|
|Last Modified:||12 Mar 2009 12:26|
|Publisher:||The American Chemical Society|