Peacock, C.S., Seeger, K., Harris, D. et al. (39 more authors) (2007) Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nature Genetics, 39 (7). pp. 839-847. ISSN 1061-4036
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
|Institution:||The University of York|
|Academic Units:||The University of York > Biology (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||19 Mar 2009 15:47|
|Last Modified:||19 Mar 2009 15:47|
|Publisher:||Nature Publishing Group|