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Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni

Verjovski-Almeida, S., DeMarco, R., Martins, E.A.L., Guimarães, P.E.M., Ojopi, E.P.B., Paquola, A.C.M., Piazza, J.P., Nishiyama Jr, N.Y., Kitajima, J.P., Adamson, R.E., Ashton, P.D., Bonaldo, M.F., Coulson, P.S., Dillon, G.P., Farias, L.P., Gregorio, S.P., Ho, P.L., Leite, R.A., Malaquias, L.C.C., Marques, R.C.P., Miyasato, P.A., Nascimento, A.L.T.O., Ohlweiler, F.P., Reis, E.M., Ribeiro, M.A., Sá, R.G., Stukart, G.C., Soares, M.B., Gargioni, C., Kawano, T., Rodrigues, V., Madeira, A.M.B.N., Wilson, R.A., Menck, C.F.M., Setubal, J.C., Leite, L.C.C. and Dias-Neto, E. (2003) Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni. Nature Genetics, 35 (2). pp. 148-157. ISSN 1061-4036

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Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampling of an estimated 14,000 gene complement. By analyzing automated Gene Ontology assignments, we provide a detailed view of important S. mansoni biological systems, including characterization of metazoa-specific and eukarya-conserved genes. Phylogenetic analysis suggests an early divergence from other metazoa. The data set provides insights into the molecular mechanisms of tissue organization, development, signaling, sexual dimorphism, host interactions and immune evasion and identifies novel proteins to be investigated as vaccine candidates and potential drug targets.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Biology (York)
Depositing User: York RAE Import
Date Deposited: 26 Mar 2009 12:10
Last Modified: 26 Mar 2009 12:10
Published Version: http://dx.doi.org/10.1038/ng1237
Status: Published
Publisher: Nature Publishing Group
Identification Number: 10.1038/ng1237
URI: http://eprints.whiterose.ac.uk/id/eprint/7047

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