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Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors

Peers, C. and Kemp, P.J. (2001) Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Research, 2 (3). pp. 145-149. ISSN 1465-9921

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Abstract

Airway neuroepithelial bodies sense changes in inspired O2, whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face of a potentially deleterious O2 supply. One unifying theme underpinning chemotransduction in these tissues is K+ channel inhibition. However, the transduction components, from O2 sensor to K+ channel, display considerable tissue specificity yet result in analogous end points. Here we highlight how emerging data are contributing to a more complete understanding of O2 chemosensing at the molecular level.

Item Type: Article
Copyright, Publisher and Additional Information: © 2001 BioMed Central Ltd.
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Cardiovascular Research Institute at Leeds (CRISTAL)
Depositing User: Repository Officer
Date Deposited: 13 Mar 2006
Last Modified: 04 Jun 2014 18:31
Published Version: http://respiratory-research.com/content/2/3/145
Status: Published
Refereed: Yes
Identification Number: 10.1186/rr51
URI: http://eprints.whiterose.ac.uk/id/eprint/70

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