McGrath, M.J. and O'Brien, P. (2005) Catalytic asymmetric deprotonation using a ligand exchange approach. Journal Of The American Chemical Society, 127 (47). pp. 16378-16379. ISSN 0002-7863
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Published Version: http://dx.doi.org/10.1021/ja056026d
Abstract
A novel ligand exchange approach to catalytic asymmetric deprotonation−electrophilic trapping has been developed that uses 1.3 equiv of s-BuLi, 0.06−0.2 equiv of chiral diamine ((−)-sparteine or a (+)-sparteine surrogate), and 1.2 equiv of achiral bispidine. The methodology is illustrated with a range of examples and gives access to either enantiomer of useful chiral products in good yields using substoichiometric amounts of chiral diamines.
| Item Type: | Article |
|---|---|
| Academic Units: | The University of York > Chemistry (York) |
| Depositing User: | York RAE Import |
| Date Deposited: | 03 Apr 2009 11:00 |
| Last Modified: | 03 Apr 2009 11:00 |
| Published Version: | http://dx.doi.org/10.1021/ja056026d |
| Status: | Published |
| Publisher: | ACS American Chemical Society |
| Identification Number: | 10.1021/ja056026d |
| URI: | http://eprints.whiterose.ac.uk/id/eprint/6902 |
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