Anjum, M.F., Stevanin, T.M., Read, R.C. and Moir, J.W.B. (2002) Nitric oxide metabolism in Neisseria meningitidis. Journal of Bacteriology, 184 (11). pp. 2987-2993. ISSN 0021-9193
Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.
|Institution:||The University of York|
|Academic Units:||The University of York > Biology (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||01 May 2009 10:44|
|Last Modified:||01 May 2009 10:44|
|Publisher:||American Society for Microbiology|