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Nitric oxide metabolism in Neisseria meningitidis

Anjum, M.F., Stevanin, T.M., Read, R.C. and Moir, J.W.B. (2002) Nitric oxide metabolism in Neisseria meningitidis. Journal of Bacteriology, 184 (11). pp. 2987-2993. ISSN 0021-9193

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Abstract

Neisseria meningitidis, the causative agent of meningococcal disease in humans, is likely to be exposed to nitrosative stress during natural colonization and disease. The genome of N. meningitidis includes the genes aniA and norB, predicted to encode nitrite reductase and nitric oxide (NO) reductase, respectively. These gene products should allow the bacterium to denitrify nitrite to nitrous oxide. We show that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite. NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO. Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Biology (York)
Depositing User: York RAE Import
Date Deposited: 01 May 2009 10:44
Last Modified: 01 May 2009 10:44
Published Version: http://dx.doi.org/10.1128/JB.184.11.2987-2993.2002
Status: Published
Publisher: American Society for Microbiology
Identification Number: 10.1128/JB.184.11.2987-2993.2002
URI: http://eprints.whiterose.ac.uk/id/eprint/6599

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