Torres-Cruz, J. and Van der Woude, M.W. (2003) Slipped-strand mispairing can function as a phase variation mechanism in Escherichia coli. Journal of Bacteriology, 185 (23). pp. 6990-6994. ISSN 0021-9193
Slipped-strand mispairing (SSM) has not been identified as a mechanism of phase variation in Escherichia coli. Using a reporter gene, we show that sequences that cause phase variation by SSM in Haemophilus influenzae also lead to phase variation when introduced onto the chromosome of E. coli, and the frequencies of switching are in the biologically relevant range. Thus, the absence of SSM-mediated phase variation in E. coli does not appear to be due to a mechanistic constraint.
|Institution:||The University of York|
|Academic Units:||The University of York > Hull York Medical School (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||23 Apr 2009 11:08|
|Last Modified:||23 Apr 2009 11:08|
|Publisher:||American Society for Microbiology|