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CD133, a novel marker for human prostatic epithelial stem cells

Richardson, G.D., Robson, C.N., Lang, S.H., Neal, D.E., Maitland, N. and Collins, A.T. (2004) CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science, 117 (16). pp. 3539-3545. ISSN 0021-9533

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Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2ß1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2ß1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Biology (York)
Depositing User: York RAE Import
Date Deposited: 05 May 2009 11:07
Last Modified: 04 Aug 2009 17:59
Published Version: http://dx.doi.org/10.1242/jcs.01222
Status: Published
Publisher: Company of Biologist Ltd
Identification Number: 10.1242/jcs.01222
URI: http://eprints.whiterose.ac.uk/id/eprint/6536

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