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Syntheses and structures of M(L)(X)BPh4 complexes {M = Co(II), Zn(II); L = cis-1,3,5-tris[3-(2-furyl)prop-2- enylideneamino]cyclohexane, X = OAc, NO3}: structural models of the active site of carbonic anhydrase

Cronin, L., Foxon, S.P., Lusby, P.J. and Walton, P.H. (2001) Syntheses and structures of M(L)(X)BPh4 complexes {M = Co(II), Zn(II); L = cis-1,3,5-tris[3-(2-furyl)prop-2- enylideneamino]cyclohexane, X = OAc, NO3}: structural models of the active site of carbonic anhydrase. Journal Of Biological Inorganic Chemistry, 6 (4). pp. 367-377. ISSN 0949-8257

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Abstract

The metal coordination geometries in the structures of the zinc(II) and cobalt(II) complexes of the ligand cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane (fr-protach) and with the anions nitrate and acetate are structural models for the active site of carbonic anhydrase. The acetate structures show a striking structural correlation with the metal coordination environments in the known bicarbonate forms of the enzyme. Such structures provide a basis for understanding the marked effect of different metal substitution on the catalytic rate of the enzyme.

Item Type: Article
Keywords: Carbonic anhydrase; Triaminocyclohexane; Biomimicry; Zinc; Cobalt
Institution: The University of York
Academic Units: The University of York > Chemistry (York)
Depositing User: York RAE Import
Date Deposited: 29 May 2009 11:08
Last Modified: 29 May 2009 11:08
Published Version: http://dx.doi.org/10.1007/s007750100211
Status: Published
Publisher: Springer Science + Business Media
Refereed: Yes
Identification Number: 10.1007/s007750100211
URI: http://eprints.whiterose.ac.uk/id/eprint/6506

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