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Stromal cells direct local differentiation of regulatory dendritic cells

Svensson, M., Maroof, A., Ato, M. and Kaye, P.M. (2004) Stromal cells direct local differentiation of regulatory dendritic cells. Immunity, 21 (6). pp. 805-816. ISSN 1074-7613

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CD11chi dendritic cells (DC) play an essential role during the initiation of cell-mediated immunity. Recently, CD11cloCD45RBhi DC with regulatory properties have been described. However, the origins of regulatory DC are poorly understood. Here, we show that spleen-derived stromal cells promote selective development of CD11cloCD45RB+ IL-10-producing regulatory DC from lineage-negative c-kit+ progenitor cells. These DC have the capacity to suppress T cell responses and induce IL-10-producing regulatory T cells in vitro and to induce antigen-specific tolerance in vivo. Furthermore, stromal cells from mice infected with Leishmania donovani more effectively supported differentiation of these highly potent regulatory DC. The ability of tissue stromal cells to direct the development of DC with a regulatory phenotype thus provides a new mechanism for local immune regulation.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Biology (York)
Depositing User: York RAE Import
Date Deposited: 22 May 2009 09:51
Last Modified: 22 May 2009 09:51
Published Version: http://dx.doi.org/10.1016/j.immuni.2004.10.012
Status: Published
Publisher: Elsevier B.V.
Identification Number: 10.1016/j.immuni.2004.10.012
URI: http://eprints.whiterose.ac.uk/id/eprint/6313

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