Coyle, D and Drummond, M F (2001) Analyzing differences in the costs of treatment across centers within economic evaluations. International Journal of Technology Assessment in Health Care. pp. 155-163. ISSN 0266-4623Full text available as:
Objectives: Assessments of health technologies increasingly include economic evaluations conducted alongside clinical trials. One particular concern with economic evaluations conducted alongside clinical trials is the generalizability of results from one setting to another. Much of the focus relating to this topic has been on the generalizability of results between countries, However, the characteristics of clinical trial design require further consideration of the generalizability of cost data between centers within a single country, which could be important in decisions about adoption of the new technology. Methods: We used data from a multicenter clinical trial conducted in the United Kingdom to assess the degree of variation in costs between patients and between treatment centers and the determinants of the degree of such variation. Results: The variation between patients was statistically significant for both the experimental and conventional treatments. However, the degree of variation between centers was only statistically significant for the experimental treatment. Such variation appeared to be a result of hospital practice, such as pay ment mechanisms for staff and provision of hostel accommodation, rather than variations in physical resource use or substantive differences in cost structure. Conclusions: Multicenter economic evaluations are necessary for determining the variations in hospital practice and characteristics that can in turn determine the generalizability of study results to other settings. Such analyses can identify issues that may be important in adopting a new health technology. Analysis is required of similar large multicenter trials to confirm these conclusions.
|Copyright, Publisher and Additional Information:||Copyright © 2001 Cambridge University Press|
|Keywords:||cost-effectiveness, external validity, multicenter clinical trials, MULTINATIONAL CLINICAL-TRIALS, ALONGSIDE|
|Academic Units:||The University of York > Centre for Health Economics (York)|
|Depositing User:||Sherpa Assistant|
|Date Deposited:||26 Aug 2005|
|Last Modified:||17 Oct 2013 14:36|