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Specific infections, infection-related behavior, and risk of non-Hodgkin lymphoma in adults

Vajdic, C.M., Grulich, A.E., Kaldor, J.M., Fritschi, L., Benke, G., Hughes, A.M., Kricker, A., Turner, J.J., Milliken, S. and Armstrong, B.K. (2006) Specific infections, infection-related behavior, and risk of non-Hodgkin lymphoma in adults. Cancer Epidemiology Biomarkers & Prevention, 15 (6). pp. 1102-1108. ISSN 1055-9965

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Abstract

Infections were examined as possible risk factors for non-Hodgkin lymphoma in a population-based case-control study in New South Wales and the Australian Capital Territory, Australia. Incident cases (n = 694) had no history of HIV infection or transplantation. Controls (n = 694) were randomly selected from electoral rolls and frequency matched to cases by age, sex, and area of residence. A postal questionnaire and telephone interview measured history of specific infections, occupational exposures, and behavioral and other risk factors for infection. Blood samples were tested for antibodies to human T-lymphotrophic virus type I and hepatitis C virus. Logistic regression models included the three matching variables and ethnicity. There was no association between risk of non-Hodgkin lymphoma and any of the variables analyzed, including sexually transmitted infections, sexual behavior, blood transfusions, influenza, acne, and either occupational or domestic exposure to zoonotic infections. Non-Hodgkin lymphoma risk was nonsignificantly elevated (odds ratio, 2.99; 95% confidence interval, 0.78-11.51) for those with a history of injecting drug use. Three cases and two controls (odds ratio, 1.32; 95% confidence interval, 0.22-7.98) tested positive to hepatitis C virus infection and none tested positive to human T-lymphotrophic virus type I/II infection. This study provides consistent evidence that sexually transmitted infections and zoonoses are not risk factors for non-Hodgkin lymphoma.

Item Type: Article
Academic Units: The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 03 Sep 2009 13:49
Last Modified: 03 Sep 2009 13:49
Published Version: http://dx.doi.org/10.1158/1055-9965.EPI-06-0078
Status: Published
Publisher: American Association for Cancer Research
Identification Number: 10.1158/1055-9965.EPI-06-0078
URI: http://eprints.whiterose.ac.uk/id/eprint/5794

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