Nelson, E.A., Iglesias, C.P., Cullum, N. et al. (1 more author) (2004) Randomized clinical trial of four-layer and short-stretch compression bandages for venous leg ulcers (VenUS I). British Journal of Surgery, 91 (10). pp. 1292-1299. ISSN 0007-1323
Background: A randomized clinical trial was undertaken to determine the relative effectiveness of four-layer and short-stretch bandaging for venous ulceration.
Methods: A total of 387 adults with a venous ulcer, who were receiving leg ulcer treatment either in primary care or as a hospital outpatient, were recruited to this parallel-group open study and randomized to either four-layer or short-stretch bandages. Follow-up continued until the patient's reference leg was ulcer free or for a minimum of 12 months. The primary endpoint was time to complete healing of all ulcers on the reference leg. Secondary outcomes included proportion of ulcers healed, health-related quality of life, withdrawals and adverse events. Analysis was by intention to treat.
Results: Unadjusted analysis identified no statistically significant difference in median time to healing: 92 days for four-layer and 126 days for short-stretch bandages. However, when prognostic factors were included in a Cox proportional hazards regression model, ulcers treated with the short-stretch bandage had a lower probability of healing than those treated with the four-layer bandage: hazard ratio 0·72 (95 per cent confidence interval 0·57 to 0·91). More adverse events and withdrawals were reported with the short-stretch bandage.
Conclusion: Venous leg ulcers treated using a four-layer bandage healed more quickly than those treated with a short-stretch bandage.
|Institution:||The University of York|
|Academic Units:||The University of York > Health Sciences (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||12 Aug 2009 10:18|
|Last Modified:||12 Aug 2009 10:18|
|Publisher:||John Wiley & Sons, Ltd|