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A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukaemia

Smith, A.G., Worrillow, L.J. and Allan, J.M. (2007) A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukaemia. Blood, 109 (109). pp. 1233-1236. ISSN 0006-4971

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Numerous structural genetic abnormalities observed in acute myeloid leukemia (AML) illustrate the heterogeneity of this disease, which likely has contributed to difficulty in identifying susceptibility alleles for AML. We previously reported that carriers of the glutamine-encoding allele at codon 751 of the xeroderma pigmentosum group D (XPD) DNA repair gene were significantly more likely to have a karyotype associated with a less favorable prognosis, and hypothesized that this observation was driven by an association between the codon 751 variant and risk of developing AML with specific structural abnormalities. Using a case series of 927 patients with AML, we show here that the XPD codon 751 glutamine-encoding variant significantly associates with risk of developing AML with a chromosome 5q deletion (odds ratio [OR] 2.09; 95% confidence interval [CI] 1.14-3.81; n = 69; P = .02) or a chromosome 7q deletion (OR 2.27; 95% CI 1.09-4.71; n = 47; P = .03), but not with any other commonly recurring cytogenetic lesion.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Biology (York)
The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 13 Aug 2009 11:27
Last Modified: 13 Aug 2009 11:27
Published Version: http://dx.doi.org/10.1182/blood-2006-07-037853
Status: Published
Publisher: American Society of Hematology
Identification Number: 10.1182/blood-2006-07-037853
URI: http://eprints.whiterose.ac.uk/id/eprint/5725

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