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Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

Fear, N.T., Roman, E., Ansell, P., Simpson, J., Day, N. and Eden, O.B. (2003) Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study. British Journal of Cancer, 89 (7). pp. 1228-1231. ISSN 0007-0920

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The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case–control study of childhood cancer, using data abstracted from obstetric and neonatal records. The analyses included 2530 children diagnosed with cancer before 15 years of age, 1174 of whom had leukaemia and 4487 control children without cancer. Overall, 39% of cases and 42% of controls had records of i.m. vitamin K administration, while 24% of cases and 22% of controls had no record of whether or not they had received vitamin K. Using subjects who received i.m. vitamin K as the baseline group, our analyses found no association between the administration of i.m. vitamin K and either leukaemia or other cancers as a group. We conclude that there is no convincing evidence that neonatal vitamin K administration, irrespective of the route by which it is given, influences the risk of children developing leukaemia or any other cancer.

Item Type: Article
Keywords: case–control study, childhood cancer, intramuscular administration, leukaemia, vitamin K
Institution: The University of York
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT)
The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 17 Aug 2009 15:12
Last Modified: 18 Jun 2015 17:27
Published Version: http://dx.doi.org/10.1038/sj.bjc.6601278
Status: Published
Publisher: Nature Publishing Group
Identification Number: 10.1038/sj.bjc.6601278
URI: http://eprints.whiterose.ac.uk/id/eprint/5699

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