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Non-Hodgkin's Lymphoma: obesity and energy homeostasis polymorphisms

Willett, E.V., Skibola, C.F., Adamson, P., Skibola, D.R., Morgan, G.J., Smith, M.T. and Roman, E. (2005) Non-Hodgkin's Lymphoma: obesity and energy homeostasis polymorphisms. British Journal of Cancer, 93 (7). pp. 811-816. ISSN 0007-0920

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A population-based case–control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over 30 kg m-2 at five years before diagnosis,, was associated with an increased risk of NHL (OR=1.5, 95% CI 1.1–2.1). The excess was most pronounced for diffuse large B-cell lymphoma (OR=1.9, 95% CI 1.3–2.8). Genetic variants in the leptin (LEP 19G>A, LEP -2548G>A) and leptin receptor genes (LEPR 223Q>R), previously shown to modulate NHL risk, as well as a polymorphism in the energy regulatory gene adiponectin (APM1 276G>T), were investigated. Findings varied with leptin genotype, the risks being decreased with LEP 19AA (OR=0.7, 95% CI 0.5–1.0) and increased with LEP -2548GA (OR=1.3, 95% CI 1.0–1.7) and -2548AA (OR=1.4, 95% CI 1.0–1.9), particularly for follicular lymphoma. These genetic findings, which were independent of BMI, were stronger for men than women.

Item Type: Article
Keywords: non-Hodgkin's lymphoma, body mass index, SNP, leptin, adiponectin, epidemiology
Institution: The University of York
Academic Units: The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 17 Aug 2009 15:28
Last Modified: 17 Aug 2009 15:28
Published Version: http://dx.doi.org/10.1038/sj.bjc.6602762
Status: Published
Publisher: Nature Publishing Group
Identification Number: 10.1038/sj.bjc.6602762
URI: http://eprints.whiterose.ac.uk/id/eprint/5690

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