Phillips, G.D., Setzu, E. and Hitchcott, P.K. (2003) Facilitation of appetitive Pavlovian conditioning by d-amphetamine in the shell, but not the core, of the nucleus accumbens. Behavioral Neuroscience, 117 (4). pp. 675-684. ISSN 0735-7044
The effects of postsession d-amphetamine within subregions of the ventral and dorsal striatum on appetitive Pavlovian learning were assessed. Rats acquired a conditioned approach response on presentation of a stimulus predictive of 10% sucrose solution (unconditioned stimulus [US]), but not during equally frequent presentations of a stimulus uncorrelated with the US. In Experiment 1, postsession d-amphetarnine infusions enhanced acquisition of conditioned responding, with no effect on control measures. In Experiment 2, rats received postsession d-amphetamine in the accumbens shell or core. Shell infusions facilitated conditioning; core infusions did not. In Experiment 3, dorsomedial striatal infusions of d-amphetamine also were ineffective. In sum, dopaminergic activation within the shell, but not the core, of the nucleus accumbens facilitates the acquisition of a Pavlovian association.
|Institution:||The University of York|
|Academic Units:||The University of York > Psychology (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||24 Jul 2009 08:21|
|Last Modified:||24 Jul 2009 08:21|
|Publisher:||American Psychological Association|