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Facilitation of appetitive Pavlovian conditioning by d-amphetamine in the shell, but not the core, of the nucleus accumbens

Phillips, G.D., Setzu, E. and Hitchcott, P.K. (2003) Facilitation of appetitive Pavlovian conditioning by d-amphetamine in the shell, but not the core, of the nucleus accumbens. Behavioral Neuroscience, 117 (4). pp. 675-684. ISSN 0735-7044

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Abstract

The effects of postsession d-amphetamine within subregions of the ventral and dorsal striatum on appetitive Pavlovian learning were assessed. Rats acquired a conditioned approach response on presentation of a stimulus predictive of 10% sucrose solution (unconditioned stimulus [US]), but not during equally frequent presentations of a stimulus uncorrelated with the US. In Experiment 1, postsession d-amphetarnine infusions enhanced acquisition of conditioned responding, with no effect on control measures. In Experiment 2, rats received postsession d-amphetamine in the accumbens shell or core. Shell infusions facilitated conditioning; core infusions did not. In Experiment 3, dorsomedial striatal infusions of d-amphetamine also were ineffective. In sum, dopaminergic activation within the shell, but not the core, of the nucleus accumbens facilitates the acquisition of a Pavlovian association.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Psychology (York)
Depositing User: York RAE Import
Date Deposited: 24 Jul 2009 08:21
Last Modified: 24 Jul 2009 08:21
Published Version: http://dx.doi.org/10.1037/0735-7044.117.4.675
Status: Published
Publisher: American Psychological Association
Identification Number: 10.1037/0735-7044.117.4.675
URI: http://eprints.whiterose.ac.uk/id/eprint/5658

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