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GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations

Traub, R.D., Cunningham, M.O., Gloveli, T., LeBeau, F.E.N., Bibbig, A., Buhl, E.H. and Whittington, M.A. (2003) GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations. Proceedings of the National Academy of Sciences, 100 (19). pp. 11047-11052. ISSN 0027-8424

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Gamma (30–80 Hz) oscillations occur in mammalian electroencephalogram in a manner that indicates cognitive relevance. In vitro models of gamma oscillations demonstrate two forms of oscillation: one occurring transiently and driven by discrete afferent input and the second occurring persistently in response to activation of excitatory metabotropic receptors. The mechanism underlying persistent gamma oscillations has been suggested to involve gap-junctional communication between axons of principal neurons, but the precise relationship between this neuronal activity and the gamma oscillation has remained elusive. Here we demonstrate that gamma oscillations coexist with high-frequency oscillations (>90 Hz). High-frequency oscillations can be generated in the axonal plexus even when it is physically isolated from pyramidal cell bodies. They were enhanced in networks by nonsomatic -aminobutyric acid type A (GABAA) receptor activation, were modulated by perisomatic GABAA receptor-mediated synaptic input to principal cells, and provided the phasic input to interneurons required to generate persistent gamma-frequency oscillations. The data suggest that high-frequency oscillations occurred as a consequence of random activity within the axonal plexus. Interneurons provide a mechanism by which this random activity is both amplified and organized into a coherent network rhythm.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2003 by the National Academy of Sciences
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Membrane and Systems Biology (Leeds)
Depositing User: Sherpa Assistant
Date Deposited: 14 Mar 2006
Last Modified: 04 Jun 2014 21:14
Published Version: http://www.pnas.org/cgi/content/full/100/19/11047
Status: Published
Refereed: Yes
Identification Number: 10.1073/pnas.1934854100
URI: http://eprints.whiterose.ac.uk/id/eprint/564

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