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A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro

Cunningham, M.O., Whittington, M.A., Bibbig, A., Roopun, A., LeBeau, F.E.N., Vogt, A., Monyer, H., Buhl, E.H. and Traub, R.D. (2004) A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro. Prcoeedings of the National Academy of Sciences, 101 (18). pp. 7152-7157. ISSN 0027-8424

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Abstract

Basic cellular and network mechanisms underlying gamma frequency oscillations (30–80 Hz) have been well characterized in the hippocampus and associated structures. In these regions, gamma rhythms are seen as an emergent property of networks of principal cells and fast-spiking interneurons. In contrast, in the neocortex a number of elegant studies have shown that specific types of principal neuron exist that are capable of generating powerful gamma frequency outputs on the basis of their intrinsic conductances alone. These fast rhythmic bursting (FRB) neurons (sometimes referred to as "chattering" cells) are activated by sensory stimuli and generate multiple action potentials per gamma period. Here, we demonstrate that FRB neurons may function by providing a large-scale input to an axon plexus consisting of gap-junctionally connected axons from both FRB neurons and their anatomically similar counterparts regular spiking neurons. The resulting network gamma oscillation shares all of the properties of gamma oscillations generated in the hippocampus but with the additional critical dependence on multiple spiking in FRB cells.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2004 by the National Academy of Sciences
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Membrane and Systems Biology (Leeds)
Depositing User: Sherpa Assistant
Date Deposited: 13 Mar 2006
Last Modified: 08 Feb 2013 17:01
Published Version: http://www.pnas.org/cgi/content/full/101/18/7152
Status: Published
Refereed: Yes
Identification Number: 10.1073/pnas.0402060101
URI: http://eprints.whiterose.ac.uk/id/eprint/563

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