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Hypoglycaemia in Type 2 diabetes

Heller, S. (2008) Hypoglycaemia in Type 2 diabetes. Diabetes Research and Clinical Practice, 82 (S2). S108-S111. ISSN 0168-8227

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Abstract

Rates of hypoglycaemia in those with Type 2 diabetes newly started on insulin are less than in Type 1 diabetes but rise with time. As insulin secretion declines, the ability to release glucagon is diminished. Adrenaline release partially compensates for deficient glucagon secretion but is vulnerable to repeated hypoglycaemia leading to diminished sympathoadrenal activation. Thus the inevitable decline in endogenous insulin, eventually produces a similar failure of physiological protection to hypoglycaemia as in Type 1 diabetes

Item Type: Article
Copyright, Publisher and Additional Information: © 2008 Elsevier. This is an author produced version of a paper published in Diabetes Research and Clinical Practice. Uploaded in accordance with the publisher's self archiving policy.
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield)
Depositing User: Sherpa Assistant
Date Deposited: 05 Feb 2009 10:16
Last Modified: 08 Feb 2013 16:57
Published Version: http://dx.doi.org/10.1016/j.diabres.2008.09.026
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: 10.1016/j.diabres.2008.09.026
URI: http://eprints.whiterose.ac.uk/id/eprint/5590

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