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A model of peak amplitude enhancement in orthogonal two-dimensional gas chromatography

Lee, A.L., Bartle, K.D. and Lewis, A.C. (2001) A model of peak amplitude enhancement in orthogonal two-dimensional gas chromatography. Analytical Chemistry, 73 (6). pp. 1330-1335. ISSN 0003-2700

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Increases in peak capacity that are achieved using comprehensive rather than single-column gas chromatography are also often accompanied by significant improvements in minimum detectable amounts. Comprehensive gas chromatography utilizes a zone compression of eluent between primary and secondary chromatography columns, with complete conservation of mass. In this paper, we present a theoretical model of peak amplitude enhancement based on translation of the fractional area under the primary column normal curve to a secondary Gaussian peak. Amplitude enhancement made by peak modulation scales with increasing modulation period and primary column peak width. An exponential relationship between the modulated secondary column peak width and the amplitude enhancement is also observed. The calculated amplitude gains are further corrected for detector current noise generated via flame ionization detection at a range of operating frequencies. An example of trace level atmospheric analysis is used to demonstrate both peak capacity and sensitivity enhancements using the multidimensional technique.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Chemistry (York)
Depositing User: York RAE Import
Date Deposited: 23 Jul 2009 15:29
Last Modified: 23 Jul 2009 15:29
Published Version: http://dx.doi.org/10.1021/ac001120s
Status: Published
Publisher: American Chemical Society
Identification Number: 10.1021/ac001120s
URI: http://eprints.whiterose.ac.uk/id/eprint/5545

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