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Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro

Cunningham, M.O., Halliday, D.M., Davies, C.H., Traub, R.D., Buhl, E.H. and Whittington, M.A. (2004) Coexistence of gamma and high-frequency oscillations in rat medial entorhinal cortex in vitro. Journal of Physiology, 559 (2). pp. 347-353. ISSN 0022-3751

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High frequency oscillations (> 80–90 Hz) occur in neocortex and hippocampus in vivo where they are associated with specific behavioural states and more classical EEG frequency bands. In the hippocampus in vitro these oscillations can occur in the absence of pyramidal neuronal somatodendritic compartments and are temporally correlated with on-going, persistent gamma frequency oscillations. Their occurrence in the hippocampus is dependent on gap-junctional communication and it has been suggested that these high frequency oscillations originate as collective behaviour in populations of electrically coupled principal cell axonal compartments. Here we demonstrate that the superficial layers of medial entorhinal cortex can also generate high frequency oscillations associated with gamma rhythms. During persistent gamma frequency oscillations high frequency oscillations occur with a high bispectral coherence with the field gamma activity. Bursts of high frequency oscillations are temporally correlated with both the onset of compound excitatory postsynaptic potentials in fast-spiking interneurones and spikelet potentials in both pyramidal and stellate principal neurones. Both the gamma frequency and high frequency oscillations were attenuated by the gap junction blocker carbenoxolone. These data suggest that high frequency oscillations may represent the substrate for phasic drive to interneurones during persistent gamma oscillations in the medial entorhinal cortex.

Item Type: Article
Copyright, Publisher and Additional Information: Open access copy available from the journal web site.
Institution: The University of York, The University of Leeds
Academic Units: The University of York > Electronics (York)
The University of Leeds > Faculty of Biological Sciences (Leeds)
Depositing User: Open Access From Journal
Date Deposited: 23 Dec 2008 10:54
Last Modified: 15 Dec 2010 15:44
Published Version: http://dx.doi.org/10.1113/jphysiol.2004.068973
Status: Published
Publisher: Wiley-Blackwell
Refereed: Yes
Identification Number: 10.1113/jphysiol.2004.068973
URI: http://eprints.whiterose.ac.uk/id/eprint/5084

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