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Treatment allocation by minimisation

Altman, D.G and Bland, J.M (2005) Treatment allocation by minimisation. BMJ, 330 (7495). p. 843. ISSN 0959-535X

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In almost all controlled trials treatments are allocated by randomisation. Blocking and stratification can be used to ensure balance between groups in size and patient characteristics. But stratified randomisation using several variables is not effective in small trials. The only widely acceptable alternative approach is minimisation, a method of ensuring excellent balance between groups for several prognostic factors, even in small samples. With minimisation the treatment allocated to the next participant enrolled in the trial depends (wholly or partly) on the characteristics of those participants already enrolled. The aim is that each allocation should minimise the imbalance across multiple factors.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Health Sciences (York)
Depositing User: Repository Officer
Date Deposited: 18 Nov 2008 12:13
Last Modified: 18 Nov 2008 12:13
Published Version: http://dx.doi.org/10.1136/bmj.330.7495.843
Status: Published
Publisher: BMJ Publishing
Refereed: Yes
Identification Number: 10.1136/bmj.330.7495.843
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/4846

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