Altman, D.G and Bland, J.M (2005) Treatment allocation by minimisation. BMJ, 330 (7495). p. 843. ISSN 0959-535XFull text not available from this repository.
In almost all controlled trials treatments are allocated by randomisation. Blocking and stratification can be used to ensure balance between groups in size and patient characteristics. But stratified randomisation using several variables is not effective in small trials. The only widely acceptable alternative approach is minimisation, a method of ensuring excellent balance between groups for several prognostic factors, even in small samples. With minimisation the treatment allocated to the next participant enrolled in the trial depends (wholly or partly) on the characteristics of those participants already enrolled. The aim is that each allocation should minimise the imbalance across multiple factors.
|Academic Units:||The University of York > Health Sciences (York)|
|Depositing User:||Repository Officer|
|Date Deposited:||18 Nov 2008 12:13|
|Last Modified:||18 Nov 2008 12:13|
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